发明名称 AMINOPYRAZOLE DERIVATIVE
摘要 A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a C 6-10 aryl group; R 1 and R 2 independently represent H, OH, X, CN, NO 2 a C 1-4 haloalkyl group, a C 1-6 alkyl group, or the like <R 1 and R 2 together form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group>; R 3 represents H, a C 1-5 alkyl group, a C 6-10 aryl group, a C 1-5 alkyl group, or a C 1-4 haloalkyl group; and R 4 represents H, X, a C 1-3 alkyl group, a C 1-4 haloalkyl group, OH, CN, NO 2 or the like.)
申请公布号 SI2471786(T1) 申请公布日期 2016.03.31
申请号 SI20100031114T 申请日期 2010.08.05
申请人 CHUGAI SEIYAKU KABUSHIKI KAISHA;F. HOFFMANN-LA ROCHE AG 发明人 TAKA NAOKI;OHMORI MASAYUKI;TAKAMI KYOKO;MATSUSHITA MASAYUKI;HAYASE TADAKATSU;HYODO IKUMI;KOCHI MASAMI;NISHII HIROKI;EBIIKE HIROSATO;NAKANISHI YOSHITO;MIO TOSHIYUKI;WANG LISHA;ZHAO WEILI
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