CARTRIDGE DEVICE WITH SEGMENTED FLUIDICS FOR ASSAYING COAGULATION IN FLUID SAMPLES

摘要

The present invention relates to analytical testing devices comprising segmented fluidics and methods for assaying coagulation in a fluid sample received within the segmented fluidics. For example, the present invention may be directed to sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region. The sample analysis cartridge further includes a pump configured to independently mix the first segment in the second conduit and the second segment in the third conduit, and independently position the first segment over the first sensor region and position the second segment over the second sensor region.

主权项

1. A sample analysis cartridge comprising:
an inlet chamber configured to receive a biological sample; a first conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the first conduit comprising a first junction configured to split the biological sample into at least first and second segments; a second conduit fluidically connected to the first conduit at the first junction and configured to receive the first segment of the biological sample, the second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve; a third conduit fluidically connected to the first conduit at the first junction and configured to receive the second segment of the biological sample, the third conduit comprising a first flow restrictor region, a second reagent, and a second sensor region; and a pump configured to:
independently mix the first segment in the second conduit to dissolve the first reagent into the first segment and mix the second segment in the third conduit to dissolve the second reagent into the second segment; andindependently position the first segment over the first sensor region and position the second segment over the second sensor region.