发明名称 |
Method for inhibiting cellular activation by insulin-like growth factor-1 |
摘要 |
Disclosed is a monoclonal antibody that specifically binds an epitope within amino acids 71-80 of the human IAP (integrin-associated protein) and is an antagonist of IAP to SHPS-1 (Src homology 2 domain-containing protein tyrosine phosphatase substrate 1) binding. Also disclosed is a method of inhibiting IGF-1 actions in a subject by the use of the antibody. |
申请公布号 |
NZ621515(A) |
申请公布日期 |
2016.03.31 |
申请号 |
NZ20120621515 |
申请日期 |
2012.08.24 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
CLEMMONS DAVID R.;MAILE LAURA A. |
分类号 |
A61K39/395;A61K38/30;A61P29/00;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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