| 摘要 |
THE PRESENT INVENTION IS CONCERNED WITH ISOXAZOLE-PYRIDINE DERIVATIVES OF FORMULA (I) WHEREIN: X IS O OR NH; R1 IS PHENYL, PYRIDINYL, OR PYRIMIDINYL, EACH OPTIONALLY SUBSTITUTED WITH 1, 2 OR 3 HALO, R2 IS H OR CH3 OR CF3; R3, R4, R5 AND R6 ARE EACH INDEPENDENTLY H OPTIONALLY SUBSTITUTED C1-7ALKYL OPTIONALLY SUBSTITUTED C1-7ALKOXY CN, HALO, NO2, S-C1-7ALKYL, S(O)-C1-7ALKYL OPTIONALLY SUBSTITUTED BENZYLOXY -C(O)-RA,- C(O)-NRB RC OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF . THE COMPOUNDS ARE ACTIVE ON THE GABA A ?5 RECEPTOR BINDING SITE AND USEFUL FOR THE TREATMENT OF COGNITIVE DISORDERS, SUCH AS ALZHEIMER?S DISEASE. |
