| 摘要 |
Disclosed are bi-substituted -amino-pyrido[4,3-d]pyrimidine-5(6H)-one derivatives as represented by the general formula (I), wherein the variables are as defined in the specification. These compounds are suitable for treating neurodegenerative disease such as Parkinson’s disease or Alzheimer’s disease, and inflammatory disease selected from asthma, chronic obstructive pulmonary disease (COPD), adult respiratory distress syndrome (ARDs), ulcerative colitis, Crohn’s disease, bronchitis, dermatitis, allergic rhinitis, psorasis, scleroderma, urticaria, rheumatoid arthritis, multiple sclerosis, or cancer. |
