| 摘要 |
The invention relates to a method of providing a prognosis for a pregnancy comprising subjecting a sample to direct mass spectral analysis, and comparing the spectra resulting from said analysis to spectra generated from samples obtained from5 normal pregnancies. The invention describes subjecting a sample of maternal bodily fluid and/or fluids in which an embryo is cultured, or kept in, to direct matrix assisted laser desorption time of flight mass spectrometry and detection of spectral masses between 2,000 and 100,000 m/z. The changes in spectral masses, leading to changes in the profile of the spectra, are characteristic of disorders of fetal development and10 pregnancy. |
