| 摘要 |
Discloses a non-naturally occurring fusion protein comprising (i) a zinc finger protein that binds to an endogenous albumin gene and (ii) a cleavage domain, wherein the fusion protein cleaves the endogenous albumin gene, and wherein the zinc finger protein comprises 4, 5, or 6 zinc finger domains, each zinc finger domain comprising a recognition helix region, wherein the zinc finger proteins comprise the recognition helix regions shown in a single row of Table 1, Table 3, Table 5 or Table 8. Also discloses use of such a protein to treat for cleaving albumin and treating A1AT-deficiency disorders. |
