发明名称 |
Cylodextrin complexation methods for formulating peptide proteasome inhibitors |
摘要 |
This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration. Many peptide proteasome inhibitors have been shown to have low solubility in water. |
申请公布号 |
NZ602490(A) |
申请公布日期 |
2016.03.31 |
申请号 |
NZ20120602490 |
申请日期 |
2012.09.13 |
申请人 |
ONYX THERAPEUTICS INC. |
发明人 |
SHWONEK PETER;JUMAA MOUHANNAD;LEWIS EVAN;DALZIEL SEAN |
分类号 |
A61K47/48;A61K38/07;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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