发明名称 |
Novel process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline |
摘要 |
The present disclosure provides a new process of synthesis of a polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline of Formula I. Said quinoline compound is substantially pure of any impurities. The present invention further provides the use of the above-mentioned polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline in the synthesis of piperaquine or one of its pharmaceutically acceptable salts. |
申请公布号 |
NZ617294(A) |
申请公布日期 |
2016.03.31 |
申请号 |
NZ20120617294 |
申请日期 |
2012.06.05 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
CABRI WALTER;CASTAGNANI ROBERTO;ARMAROLI SILVIA;QUATTROCIOCCHI GIANANDREA;COLANGELI VINCENZO |
分类号 |
C07D215/46;C07D401/04 |
主分类号 |
C07D215/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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