REMOVAL OF FRAGMENTS FROM A SAMPLE CONTAINING A TARGET PROTEIN USING ACTIVATED CARBON

摘要

The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal, of protein, fragments without adversely affecting the yield of the desired protein product.

主权项

1. A method of reducing the amount of fragments in a sample comprising a target protein to be purified, the method comprising the steps of:
(a) providing a sample comprising a target protein and fragments of the target protein, wherein the fragments are in an amount equal to or greater than at least 0.2% of the amount of the target protein, (b) contacting the sample with activated carbon, wherein the activated carbon binds the fragments, (c) removing the activated carbon from the sample, thereby reducing the amount of the fragments in the sample.