| 摘要 |
Disclosed are inhibitory compounds of a p38 MAP kinase with a structure of type (I), which can be used for the treatment or prophylaxis of adhesion, wherein R1 represents the water soluble polymers chitosan, polyvinyltetrazole, carboxymethyl cellulose salts, polyvinylimidazole, polyethylenimine, polyvinylpyridines, polyvinyltriazole, polyacrylic acid salts, and polymethacrylic acid salts. The water soluble polymers form conjugates with the p38 MAP kinase inhibitor compound SB203580 (4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine). Also disclosed are methods for the prophylaxis and/or treatment of a disease or a condition in which there is the possibility of the formation and/or growth of adhesions in the serous cavity which makes it possible to dispense with the additional administration of a preparation in the post-operative period. |
