Mixed crystalline form-viii of agomelatine, its method of preparation, application and pharmaceutical use

摘要

Provided herein is a mixed crystal agomelatine (Form-VIII), the preparation method and use thereof and a pharmaceutical composition containing the same, wherein the mixed crystal mainly contains an agomelatine crystal form VI. The mixed crystal is stable and has good reproducibility, and is found through a stability test to be superior to a crystal form VI in terms of stability. Therefore, the Form-VIII of agomelatine has an advantage in terms of preparation.