Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals

摘要

Provided are substituted 2-(chroman-6-yloxy)-thiazole compounds of the general formula I, where the variables are as defined in the specification. Examples of the compounds include 2-(2-o-Tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid [2-(2-oxo-imidazolidin-1-yl)ethyl]-amide and [2-(2-Phenyl-chroman-6-yloxy)-thiazol-5-ylmethyl]-pyridin-4-ylmethyl-amine. The compounds sodium-calcium exchanger (NCX) inhibitors. The compounds may be useful in the treatment of arrhythmias, heart failure and stroke.