HYALURONIC ACID-COLLAGEN MATRICES FOR DERMAL FILLING AND VOLUMIZING APPLICATIONS

摘要

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

主权项

1. A method of improving aesthetic quality of a soft tissue in a human subject, the method comprising:
contacting a hydrogel composition with adipose tissue in vitro to provide a filler composition; subcutaneously injecting the filler composition into the soft tissue of the subject; and generating an additional amount of adipose tissue in the subject; wherein the hydrogel composition comprises:
(i) water; and(ii) a macromolecular matrix comprising hyaluronic acid crosslinked with collagen via a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond; and wherein the weight ratio of the hyaluronic acid to the collagen is about 2 to 1;thereby improving the aesthetic quality of the soft tissue.