CARTRIDGE DEVICE WITH FLUIDIC JUNCTIONS FOR COAGULATION ASSAYS IN FLUID SAMPLES

摘要

The present invention relates to analytical testing devices comprising fluidic junctions and methods for assaying coagulation in a fluid sample received within the fluidic junctions. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber, a first conduit comprising a first junction configured to split a biological sample into at least first and second segments, a second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve, and a third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve. The sample analysis cartridge further includes a pump configured to push the first segment over the first sensor region to the first fluidic lock valve, and push the second segment over the second sensor region to the second fluidic lock valve.

主权项

1. A sample analysis cartridge comprising:
an inlet chamber configured to receive a biological sample; a first conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the first conduit comprising a first junction configured to split the biological sample into at least first and second segments; a second conduit fluidically connected to the first conduit at the first junction and configured to receive the first segment of the biological sample, the second conduit comprising a first reagent, a first sensor region, and a first fluidic lock valve; a third conduit fluidically connected to the first conduit at the first junction and configured to receive the second segment of the biological sample, the third conduit comprising a second reagent, a second sensor region, and a second fluidic lock valve; and a pump configured to:
push the first segment over the first sensor region to the first fluidic lock valve such that the first segment is locked within the second conduit; andpush the second segment over the second sensor region to the second fluidic lock valve such that the second segment is locked within the third conduit.