| 发明名称 |
GLATIRAMER ACETATE HUMAN MONOCYTIC CELL LINE-BASED POTENCY ASSAY |
| 摘要 |
The present invention relates to a method to determine the potency of a batch of glatiramer acetate comprising stimulating human monocytic cell line cells with an effective amount of interferon gamma (IFNγ), exposing said cells to said batch of glatiramer acetate, and determining the expression of the monocyte anti-inflammatory cytokine sIL-1Ra or the viability of said cells induced by glatiramer acetate. |
| 申请公布号 |
US2016091486(A1) |
申请公布日期 |
2016.03.31 |
| 申请号 |
US201414785800 |
申请日期 |
2014.04.25 |
| 申请人 |
SYNTHON B.V. |
发明人 |
KOLEN Sebastianus Martinus Henricus;WEIJTS Francisca Antoinette Adriana |
| 分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method to determine the potency of a batch of glatiramer acetate comprising stimulating human monocytic cell line cells with an effective amount of interferon gamma (IFNγ), exposing said cells to said batch of glatiramer acetate (GA), and determining the expression of the monocyte anti-inflammatory cytokine sIL-1Ra or the viability of said cells induced by glatiramer acetate. |
| 地址 |
Nijmegen NL |
