| 发明名称 |
Monomethylvaline compounds capable of conjugation to ligands |
| 摘要 |
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. |
| 申请公布号 |
EP2260858(B1) |
申请公布日期 |
2016.03.30 |
| 申请号 |
EP20100175437 |
申请日期 |
2004.11.05 |
| 申请人 |
SEATTLE GENETICS, INC. |
发明人 |
DORONINA, SVETLANA O.;SENTER, PETER D.;TOKI, BRIAN E.;EBENS, ALLEN J.;KLINE, TONI BETH;POLAKIS, PAUL;SLIWKOWSKI, MARK X.;SPENCER, SUSAN D. |
| 分类号 |
A61K38/06;A61K38/00;A61K39/395;A61K47/48;C07K7/02;C07K16/46 |
主分类号 |
A61K38/06 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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