Methods

摘要

A method for identifying a subject with a disease or condition characterised by the presence of unwanted cells as being likely to respond to treatment comprising administration of a class of histone deactylase inhibitor in the cytoplasm ie a lysine deacetylase class 6 inhibitor (KDAC6) inhibitor having the structure of Formula I, wherein said method comprises determining whether the subject's unwanted cells have or are likely to have an increased dependency on autophagy for survival, and wherein Formula I comprises: The invention also relates to a therapy based on the above method and treatments for viral and diseases and cancer.