发明名称 |
DIAGNOSING AND TREATING ALZHEIMER'S DISEASE USING ANNEXINS WITH LABELED WITH A RADIONUCLIDE |
摘要 |
Alzheimer's disease is treated by attacking hyperactive microglia preferably before excessive beta amyloid is built up by administering tin-117m-DOTA annexin V. This compound in low radioactive doses selectively binds to the aged hyperactive microglia and emits a conversion electron which effectively induces apoptosis in the hyperactive microglia. A follow-up treatment of tin-annexin A1 can be administered to repair the blood brain barrier. The annexin A1 assists in the repair of the blood-brain barrier and the associated tin-117m will induce apoptosis in aged hyperactive microglia associated with the blood brain barrier. |
申请公布号 |
EP2999487(A1) |
申请公布日期 |
2016.03.30 |
申请号 |
EP20140731119 |
申请日期 |
2014.05.21 |
申请人 |
NEUROSN, INC. |
发明人 |
STEVENSON, NIGEL, R.;GONZALES, GILBERT, R. |
分类号 |
A61K51/08;A61K103/00;A61K103/10;A61P25/28 |
主分类号 |
A61K51/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|