| 摘要 |
Composition comprises: (a) at least one fused bicyclic compound (I) and their salts; and (b) at least one selective inhibitor of cyclooxygenase 2 (COX-2) or its salt, optionally combined with one or more excipients, where the composition does not contains isobutyl-benzene compound (VI) or its salt. Composition comprises: (a) at least one fused bicyclic compound of formula (I) and their salts; and (b) at least one selective inhibitor of cyclooxygenase 2 (COX-2) or its salt, optionally combined with one or more excipients, where the composition does not contains isobutyl-benzene compound of formula (VI) or its salt. R5 : O or any group; R6 : H or 1-6C alkyl; n : 2-4; j : 1-n; R j : H or 1-6C alkyl; R7 : phenyl optionally substituted by one or more H, 1-6C alkyl, 1-6C alkoxy, CF 3or halo; R8-R11 : H, 1-6C alkyl, 1-6C alkoxy, CF 3, or halo; R12 : H or 1-6C alkyl; R13 : OR14 or NR15R16; R14 : H, 1-6C alkyl, 6-10C aryl, aralkyl or 7-20C alkaryl; and R15, R16 : H, OH, 1-6C alkyl, 6-10C aryl aralkyl or 7-20C alkaryl. Independent claims are included for: (1) the fused bicyclic compound (I) in combination with a selective inhibitor of COX-2 (II); and (2) products containing: (I) and (II) as a combination product for use together or separately to induce analgesia or to prevent or treat pain, where the product is devoid of (VI). [Image] ACTIVITY : Analgesic. MECHANISM OF ACTION : None given. |
