发明名称 |
TREATMENT OF MAST CELL RELATED PATHOLOGIES |
摘要 |
Methods of inhibiting activation of a mast cell and/or treating a disease induced by activation of a mast cell in a subject are provided. Accordingly there is provided a method comprising contacting a cancerous mast cell with an effective amount of a multivalent agent which binds and activates Siglec-7, thereby inhibiting activation of the cancerous mast cell. Also provided is a method comprising contacting a mast cell with an effective amount of an agent comprising: a first moiety which binds and activates Siglec-7; and a second moiety which binds activates a mast cell activating receptor, thereby inhibiting activation of the mast cell. Also provided are agents and compositions for and methods of inhibiting activation of a mast cell and/or treating a disease induced by activation of a mast cell in a subject. |
申请公布号 |
EP2999717(A1) |
申请公布日期 |
2016.03.30 |
申请号 |
EP20140736034 |
申请日期 |
2014.05.21 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM LTD. |
发明人 |
LEVI-SCHAFFER, FRANCESCA;MIZRAHI, SAAR;BEN-ZIMRA, MICHA;KARRA, LAILA |
分类号 |
C07K16/28;A61P35/00;C07K16/42 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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