Process for the preparation of Cyclopamine analogue compounds
摘要
The present invention provides a preparation method for analogs of cyclopamine of formula 1
that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations.
The compounds of the present invention are particularly useful in treating cancers.
申请公布号
EP2316833(B1)
申请公布日期
2016.03.30
申请号
EP20100012778
申请日期
2005.08.26
申请人
INFINITY PHARMACEUTICALS, INC.
发明人
JANARDANANNAIR, SOMARAJANNAIR;ADAMS, JULIAN;TREMBLAY, MARTIN;NEVALAINEN, MARTA;CASTRO, ALFREDO C.;FOLEY, MICHAEL A.;PORTER, JAMES R.