发明名称 |
AN IMPROVED PROCESS FOR PREPARATION OF PERINDOPRIL INTERMEDIATE |
摘要 |
The present invention relates to an improved process for the preparation Of (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]3-S-oxopropyl]octahydro-1H-indole-2-carboxylic acid benzyl ester (the compound of formula II) comprising reacting (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate (the compound of formula III) with N-[(S)-ethoxycarbonyl-1-butyl]-(S)-alanine (the compound of formula IV), using 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodimide (DCC) and triethylamine in the presence of toluene as a solvent at a temperature of 5-40° C. |
申请公布号 |
EP2906536(A4) |
申请公布日期 |
2016.03.30 |
申请号 |
EP20130845500 |
申请日期 |
2013.10.04 |
申请人 |
PIRAMAL ENTERPRISES LIMITED |
发明人 |
WAGH, GANESH;JAGTAP, ASHUTOSH;ROY, MITA;HARIHARAN, SIVARAMAKRISHNAN |
分类号 |
C07D209/42;C07K5/08 |
主分类号 |
C07D209/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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