发明名称 |
MUTEINS OF HUMAN LIPOCALIN 2 (LCN2, HNGAL) WITH AFFINITY FOR A GIVEN TARGET |
摘要 |
The present invention relates to a novel library for the generation of muteins and to novel muteins derived from human lipocalin 2 (Lcn2, hNGAL) and related proteins that bind a given target with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. For example, such muteins may serve to bind and deplete pathological forms of natural biomolecules such as the amyloid beta peptide in Alzheimer's disease or may target the fibronectin extra-domain B, which is associated with tumor neovasculature. |
申请公布号 |
EP2510357(B1) |
申请公布日期 |
2016.03.30 |
申请号 |
EP20100784824 |
申请日期 |
2010.12.07 |
申请人 |
PIERIS AG |
发明人 |
SKERRA, ARNE;GEBAUER, MICHAELA;HINZ, DOMINIK;RAUTH, SABINE;MATSCHINER, GABRIELE;HUELSMEYER, MARTIN |
分类号 |
G01N33/566;C07K1/00;C07K14/775 |
主分类号 |
G01N33/566 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|