发明名称 |
RECEPTORS OF RSPO2 AND RSPO3 |
摘要 |
The present invention relates to the finding that Syndecans (Sdc) are receptors of Rspondin-2 (Rspo2) and Rspondin-3 (Rspo3). Thus, the present invention relates to the identification of Rspo2, Rspo3 and/or Sdc activity modulators by determining if a test compound has the ability to modulate the binding of an Rspo2 and/or Rspo3 polypeptide to an Sdc polypeptide. Further, the invention refers to novel uses for antagonists of Rspo2 and/or Rspo3 in the treatment of Sdc-associated disorders and for Sdc antagonists in the treatment of Rspo2- and/or Rspo3-associated disorders. |
申请公布号 |
EP2515933(B1) |
申请公布日期 |
2016.03.30 |
申请号 |
EP20100807590 |
申请日期 |
2010.12.23 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM |
发明人 |
NIEHRS, CHRISTOF;GLINKA, ANDREY;OKAWARA, BISEI |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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