PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-1,2,3,4 -TETRAHYDROQUINOLINES

摘要

The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of:
treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]:
[wherein R 1 represents a hydrogen atom or a protecting group for amino group.]
with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic
compound [I] in the presence of an acyl donor; and
if necessary, subjecting the reaction product to solvolysis.