| 发明名称 |
USE OF CART19 TO DEPLETE NORMAL B CELLS TO INDUCE TOLERANCE |
| 摘要 |
The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. |
| 申请公布号 |
EP2872184(A4) |
申请公布日期 |
2016.03.30 |
| 申请号 |
EP20130816739 |
申请日期 |
2013.07.12 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
LEVINE, BRUCE, L.;KALOS, MICHAEL, D.;JUNE, CARL, H. |
| 分类号 |
A61K48/00;A61K35/12;A61K35/17;A61K38/17;A61P37/06 |
主分类号 |
A61K48/00 |
| 代理机构 |
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