发明名称 |
METHOD FOR PREPARING INDUCED PLURIPOTENT STEM CELLS AND ITS APPLICATIONS |
摘要 |
The present invention relates to a novel method for preparing induced pluripotent stem cells (iPSCs) by introducing three genes, Oct3/4, Sox2, and Parp1, into somatic cells. The present invention also relates to the iPSCs produced by the aforementioned method. Also provided is a method of rejuvenating cells by use of a PARylated protein or an enzyme with PARylation activity. Further provided is a method for inducing the secretion of interferon-γ inducible protein-10 (IP-10) comprising administering to a subject in need thereof an effective amount of iPSCs or iPSC-CM. |
申请公布号 |
EP2904103(A4) |
申请公布日期 |
2016.03.30 |
申请号 |
EP20130844080 |
申请日期 |
2013.09.30 |
申请人 |
TAIPEI VETERANS GENERAL HOSPITAL |
发明人 |
CHIEN, YUEH;CHIOU, GUANG-YUH;YANG, YI-PING |
分类号 |
C12N15/867;A61K35/545;A61K38/45;A61K38/46;A61P1/16;A61P11/00;C12N5/10 |
主分类号 |
C12N15/867 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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