Directed surface functionalization on selected surface areas of topographical features with nanometer resolution

摘要

A method for making a single molecule receptor in a nanopore structure includes depositing a material by a physical vapor deposition (PVD) technique onto a selected interior surface of a nanochannel and functionalizing a surface of the material with a chemical compound having at least two functional groups. The material forms a patch having a diameter of about 3 to about 10,000 nanometers (nm). Also disclosed are embodiments of a nanopore structure including a single molecule receptor.

主权项

1. A method for making a single molecule receptor in a nanopore structure, the method comprising:
depositing a material by a physical vapor deposition (PVD) technique onto a selected interior surface of a nanochannel, the material forming a raised patch having a diameter of about 1 to about 100 nanometers (nm) and extending from the selected area of the interior surface to the nanochannel's opening; and functionalizing a surface of the material with a chemical compound having at least two functional groups to form the single molecule receptor; wherein the single molecule receptor is a binding site with nanometer dimensions that binds to only a single molecule of an analyte in a complex sample.