Crystalline cis-(E)-4-(3-fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]

摘要

The present invention relates to crystalline forms of cis-(E)-4-(3-Fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]-pyrido[3,4-b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these modifications, the use of these modifications as well as to a process for making the crystalline forms.

主权项

1. Crystalline form A of cis-(E)-4-(3-Fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]-pyrido[3,4-b]indol]-4-amine, which has X-ray powder diffraction peaks (CuKα radiation) at 8.7±0.2 (2Θ), 11.9±0.2 (2Θ), 17.4±0.2 (2Θ), and 27.1±0.2 (2Θ).