| 发明名称 | Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide | ||
| 摘要 | The present invention relates to the preparation of (R)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide. | ||
| 申请公布号 | US9296686(B2) | 申请公布日期 | 2016.03.29 |
| 申请号 | US201414467424 | 申请日期 | 2014.08.25 |
| 申请人 | ARDEA BIOSCIENCES, INC. | 发明人 | Maderna Andreas;Vernier Jean Michel |
| 分类号 | C07C303/00;C07C303/38;C07C317/18;C07D317/26 | 主分类号 | C07C303/00 |
| 代理机构 | Millen White Zelano and Branigan, PC | 代理人 | Millen White Zelano and Branigan, PC ;Henter Csaba;Zelano Anthony |
| 主权项 | 1. A process for preparing a compound of formula (I-a): comprising, contacting 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-methoxybenzene-1,2-diamine with a compound of formula (II-a): wherein R1 is H or an alcohol protecting group; R2 is H or an alcohol protecting group; or R1 and R2 together with the carbon atoms to which they are attached form a cyclic 1,2-diol protecting group. | ||
| 地址 | San Diego CA US | ||