| 发明名称 |
Albumin fusion proteins |
| 摘要 |
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention. |
| 申请公布号 |
US9296809(B2) |
申请公布日期 |
2016.03.29 |
| 申请号 |
US201514818972 |
申请日期 |
2015.08.05 |
| 申请人 |
Human Genome Sciences, Inc. |
发明人 |
Rosen Craig A.;Haseltine William A.;Ruben Steven M. |
| 分类号 |
C07K14/765;C07K14/505;C07K14/535;C07K14/61;C07K14/62;C07K14/56;C07K14/585;C07K14/565;C07K14/60;C07K14/55;C07K14/635;C07K14/575;C07K14/525;C07K14/555;C07K14/50;C07K7/06;C07K14/475;C07K14/51;C07K14/605;C07K14/54;C07K16/26;A61K38/00;C07K16/24;C07K14/52;C07K14/47;C07K14/655;C12N9/02 |
主分类号 |
C07K14/765 |
| 代理机构 |
|
代理人 |
Lockenour Andrea B.;Han William T. |
| 主权项 |
1. A method of treating a Type I diabetes in a patient, comprising the step of administering a therapeutically effective amount of a pharmaceutical composition comprising an albumin fusion protein consisting of two tandemly oriented GLP-1(7-36(A8G)) polypeptides and SEQ ID NO: 1038, wherein the C-terminus of said two tandemly oriented GLP-1(7-36(A8G)) polypeptides is fused to the N-terminus of SEQ ID NO: 1038. |
| 地址 |
Wilmington DE US |
