| 主权项 |
1. A compound of general formula I: in which: R1a represents a hydrogen atom or a group selected from:
—O—C1-C6-alkyl, —(CH2)r—R8, —(CH2)r—NR3R4, —(CH2)r—N(R4)C(═O)R3, —(CH2)r—N(R4)S(═O)2R3, —(CH2)r—C(═O)OR3, —(CH2)r—C(═O)NR3R4, —(CH2)r—N(R4)C(═O)OR3, —(CH2)r—N(R4)C(═O)N(H)R3, R1b represents a hydrogen atom or a group selected from:
C1-C6-alkyl-, —(CH2)r—O—(C1-C6-alkyl); or R1a and R1b together
form an oxygen atom or a —O—(C2-C6-alkylene)-O— group; R2a represents a hydrogen atom or a halogen atom or a group selected from: C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, halo-C1-C3-alkoxy-, hydroxy-, cyano-, —N(H)R5, —NR5R4; R2b represents a hydrogen atom or a halogen atom or a group selected from: C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, halo-C1-C3-alkoxy-, hydroxy-, cyano-, —N(H)R5, —NR5R4, —N(H)C(═O)R5, —N(R4)C(═O)R5, —N(H)C(═O)NR5R4, —N(R4)C(═O)NR5R4, —C(═O)N(H)R5, —C(═O)NR5R4; R2c represents a hydrogen atom or a halogen atom or a group selected from: C1-C3-alkyl-,
C1-C3-alkoxy-, halo-C1-C3-alkyl-, halo-C1-C3-alkoxy-, hydroxy-, cyano-, —N(H)R5, —NR5R4; R3 represents a hydrogen atom or a group selected from:
C1-C6-alkyl-, C2-C6-alkynyl-, C3-C6-cycloalkyl-, —(CH2)q—(C3-C6-cycloalkyl), —(CH2)q—O—(C3-C6-cycloalkyl), 3- to 10-membered heterocycloalkyl,—(CH2)q-(3- to 10-membered heterocycloalkyl),—(CH2)q—O-(3- to 10-membered heterocycloalkyl),4- to 10-membered heterocycloalkenyl,—(CH2)q-(4- to 10-membered heterocycloalkenyl),—(CH2)q—O-(4- to 10-membered heterocycloalkenyl),aryl, —(CH2)q-aryl, —(CH2)q—O-aryl, heteroaryl, —(CH2)q-heteroaryl, —(CH2)q—O-heteroaryl, —(3- to 10-membered heterocycloalkyl)-(CH2)q-(3- to 10-membered heterocycloalkyl), -(3- to 10-membered heterocycloalkyl)-(CH2)q-aryl,-(3- to 10-membered heterocycloalkyl)-(CH2)q-heteroaryl,said group being optionally substituted, identically or differently, with 1, 2, 3, 4 or 5 R8 groups; orwhen 2 R8 groups are present ortho to each other on an aryl- or heteroaryl-ring, said 2 R8 groups together form a bridge:*O(CH2)pO*, * NH(C(═O))NH*, wherein * represent the point of attachment to said aryl- or heteroaryl-ring; R4 represents a hydrogen atom or a group selected from:
C1-C6-alkyl-, —(CH2)q-aryl, C1-C6-alkoxy-C1-C6-alkyl-; or NR3R4 together represent a 3- to 10-membered heterocycloalkyl group, a benzo fused 3- to 10-membered heterocycloalkyl group or a 4- to 10-membered heterocycloalkenyl group;
said 3- to 10-membered heterocycloalkyl or 4- to 10-membered heterocycloalkenyl group being optionally substituted, one or more times, identically or differently, with halo-, hydroxyl-, cyano-, nitro-, C1-C6-alkyl-, halo-C1-C6-alkyl-, C1-C6-alkoxy-, halo-C1-C6-alkoxy-, hydroxy-C1-C6-alkyl-, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C6-cycloalkyl-, —(CH2)q-aryl, —(CH2)q-heteroaryl, —N(R4)C(═O)R5, —NR5R4 or —(CH2)r—C(═O)NR6R7; R5 represents a hydrogen atom, a C1-C6-alkyl- or a C3-C6-cycloalkyl-group; R6 represents a hydrogen atom, a C1-C6-alkyl- or a C3-C6-cycloalkyl-group; R7 represents a hydrogen atom, a C1-C6-alkyl- or a C3-C6-cycloalkyl-group; or NR6R7 together represent a 3- to 10-membered heterocycloalkyl group; R8 represents halo-, azido-, hydroxy-, oxo-(O═), cyano-, nitro-, C1-C6-alkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, halo-C1-C6-alkyl-, C1-C6-alkoxy-, halo-C1-C6-alkoxy-, hydroxy-C1-C6-alkyl-, C1-C6-alkoxy-C1-C6-alkyl-, halo-C1-C6-alkoxy-C1-C6-alkyl-, R5—O—, —C(═O)R5, —C(═O)O—R5, —OC(═O)—R5, —N(H)C(═O)R5, —N(R4)C(═O)R5, —N(H)C(═O)NR5R4, —N(R4)C(═O)NR5R4, —N(R4)C(═O)OR5, —N(H)R5, —NR5R4, —C(═O)N(H)R5, —C(═O)NR5R4, R4—S—, R4—S(═O)—, R4—S(═O)2—, —N(H)S(═O)R4, —N(R4)S(═O)R4, —S(═O)N(H)R5, —S(═O)NR5R4, —N(H)S(═O)2R4, —N(R4)S(═O)2R4, —S(═O)2N(H)R5, —S(═O)2NR5R4, —S(═O)(═NR5)R4, —S(═O)(═NR4)R5 or —N═S(═O)(R5)R4; p represents an integer of 1 or 2; q represents an integer of 1, 2 or 3; r represents an integer of 0, 1 or 2; or a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof. |
