Indolizino[3,2-c]quinoline derivatives, pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for treatment of cystic fibrosis containing the same as active ingredient

摘要

Provided are an indolizino[3,2-c]quinoline derivative, pharmaceutically acceptable salt thereof, and a method for preparing the same. The indolizino[3,2-c]quinoline derivative, pharmaceutically acceptable salt thereof may function as an agonist of cystic fibrosis conductance transmembrane regulator, and thus may be useful for an agent for preventing or treating diseases caused by degradation of activity of cystic fibrosis conductance transmembrane regulator and for a pharmaceutical composition for stimulating proliferation of stem cells.

主权项

1. An indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 or pharmaceutically acceptable salt thereof: In Chemical Formula 1, R1, R2, R3, R4 and R5 are the same or different, and each independently represents H, F, Cl, Br, I, a C1-C6 alkyl, C1-C6 alkoxy, COOR7, aryl and a heteroaryl; R6 is selected from a C1-C6 alkyl, aryl and a heteroaryl; and R7 is H or a C1-C6 alkyl, wherein any 1-3 carbon atoms of the aryl and heteroaryl are linked to a substituent that is the same or different and is independently selected from H, F, Cl, Br, I, nitro, a C1-C6 alkyl and C1-C6 alkoxy.