Multilayer tissue regeneration system

摘要

A system for growing tissue based upon layers of an inorganic matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution.

主权项

1. A tissue regeneration system comprising:
a template having thereupon at least one synthetic, degradable extracellular matrix layer; and at least one biomolecule releasably associated with the layer, the biomolecule comprising a cell-affecting portion and a matrix-binding portion, wherein the cell-affecting portion is selected from the group consisting of fibroblast growth factor 2, bone morphogenetic protein-2, bone morphogenetic protein-7 and vascular endothelial growth factor.