| 摘要 |
The present invention relates generally to a compound of formula (la): (see formula Ia) or a pharmaceutically acceptable salt thereof, wherein R11 is C1-8 alkyl, C2-8 alkenyl, C3-14 cycloalkyl, a C6-14 aryl group, a 5-14 membered heteroaryl group, a 3-14 membered cycloheteroalkyl group, C1-8 alkoxy, halo, NR13R14, C(O)OR13, C(O)NR13R14, C1-8haloalkyl, formyl, carbalkoxy, C1-8alkylOH, C(O)R13, SO2R13, C(O)NHC1-8alkylR13, NR13R14, SO2NR13R14, OCF3, NHC(O)R13, CH2OC(O)NR13R14, CH2NR13R14, NHC(O)OR13, NHC(O)NR13R14, CH2NHSO2R13, CH2NHC(O)OR13, OC(O)R13, or NHC(O)R13; R12 is H, C1-8 alkyl, a C6-14 aryl group, C1-8 haloalkyl, C1-8 alkoxy, halo, NH2, CN, OCF3, OH, C(O)NR13R14, C(O)R13, NR13R14, NHC(O)R13, SO2R13, or SO2NR13R14; and R13 and R14 are independently H, C1-8 alkyl, C2-8 alkenyl, C3-14 cycloalkyl, a C6-14 aryl group, a 5-14 membered heteroaryl group, a 3-14 membered cycloheteroalkyl group, C1-8haloalkyl, C1-8 alkylOH, or C1-8alkoxy. Such compounds may be used for the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. |
