发明名称 |
Antimalarial drug comprising alaremycin or derivative thereof as active ingredient |
摘要 |
Provided is a preventive and/or therapeutic agent for malaria, comprising, as an active ingredient, 5-acetamido-4-oxo-5-hexenoic acid (Alaremycin) or a derivative thereof. A preventive and/or therapeutic agent for malaria is used which comprises, as an active ingredient, Alaremycin or a derivative thereof represented by formula (I) (wherein R1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; R2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and R3 represents hydrogen or a methyl group).; |
申请公布号 |
US9295660(B2) |
申请公布日期 |
2016.03.29 |
申请号 |
US201113883038 |
申请日期 |
2011.11.09 |
申请人 |
Tokyo Institute of Technology;SBI Pharmaceuticals Co., Ltd. |
发明人 |
Wachi Masaaki;Sato Shigeharu;Tanaka Tohru;Takahashi Kiwamu |
分类号 |
A61K31/197;A61K31/16;A61K31/221;A61K9/00;A61K9/107;A61K9/20 |
主分类号 |
A61K31/197 |
代理机构 |
King & Spalding LLP |
代理人 |
Brivanlou Margaret B.;Serunian Leslie A.;King & Spalding LLP |
主权项 |
1. A method of treating or preventing malaria in a subject in need thereof, comprising administering to the subject Alaremycin or a derivative thereof represented by Formula (I),wherein R1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; R2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and R3 represents hydrogen or a methyl group, or a pharmaceutically acceptable salt thereof, in an amount effective to treat or prevent malaria in the subject. |
地址 |
Tokyo JP |