Customized laser epithelial ablation systems and methods

摘要

Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

主权项

1. A system to treat a region of a cornea of an eye, the region comprising an epithelial layer disposed over a stromal layer, the system comprising:
a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region; a device configured to determine a refractive optical property of the eye; a laser to generate a laser beam of an ablative radiation; a movable scan component coupled to the laser to scan the laser beam over the region; and a processor system coupled to the laser and the movable scan component, the processor system comprising a tangible medium configured to:
(1) arrange epithelial pulses of laser beam to ablate the epithelial layer and expose at least one of the stromal layer or a Bowman's membrane, the epithelial pulses arranged by the processor system in response to at least (i) the epithelial thickness map, and (ii) epithelial basis data corresponding to at least one epithelial laser pulse ablation profile for an individual pulse; and(2) arrange additional pulses of laser beam to resculpt the stromal layer in response to at least (i) the determined refractive optical property of the eye, and (ii) stromal basis data corresponding to at least one stromal laser pulse ablation profile for an individual pulse that is different from the at least one epithelial laser pulse ablation profile, wherein the at least one stromal laser pulse ablation profile has an inner portion flat curvature and the at least one epithelial laser pulse ablation profile has an inner portion flat curvature that is sized differently than the inner portion flat curvature of the at least one stromal laser pulse ablation profile, or wherein the at least one stromal laser pulse ablation profile has an inner portion convex curvature and the at least one epithelial laser pulse ablation profile has an inner portion convex curvature that is sized differently than the inner portion convex curvature of the at least one stromal laser pulse ablation profile.