发明名称 atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
摘要 The invention provides compounds, compositions and methods to treat certain inflammatory conditions and/or oncology by administering a compound that inhibits PI3K isoforms, particularly the delta isoform. It further provides specific stereoisomers of a compound useful for these methods. In particular, the compound is an optically active atropisomer of 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one.
申请公布号 BRPI1012333(A2) 申请公布日期 2016.03.29
申请号 BR2010PI12333 申请日期 2010.03.24
申请人 GILEAD CALISTOGA LLC 发明人 JERRY B. EVARTS;ROGER G. ULRICH
分类号 A61K31/52;A61P35/00;C07D473/34 主分类号 A61K31/52
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