Radioisotope generator system including activity measurement and dose calibration

摘要

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer includes pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

主权项

1. A mobile radioisotope generator system comprising:
a movable platform carrying an infusion tubing circuit, an activity detector, a dose calibrator, a computer, and a shielding assembly containing a strontium/rubidium radioisotope generator configured to generate a radioactive eluate via elution of an eluant, the infusion tubing circuit including a tubing line connected between the strontium/rubidium radioisotope generator and the dose calibrator and configured to supply a portion of radioactive eluate to the dose calibrator, the activity detector being positioned downstream of the strontium/rubidium radioisotope generator and configured to measure an activity of the radioactive eluate flowing through the infusion tubing circuit, and the computer being electronically coupled to the dose calibrator and configured to execute automated quality control testing using the dose calibrator, wherein the computer is configured to determine an activity of strontium-82 and an activity of strontium-85 in the portion of radioactive eluate through automated quality control testing using the dose calibrator, the computer is configured to control the mobile radioisotope generator system to deliver a dose of radioactive eluate to a patient during a patient infusion procedure, and the computer is further configured to prevent the patient infusion procedure if a quality control test result exceeds an allowable limit.