| 发明名称 | Means and methods for diagnosing and treating multiple sclerosis | ||
| 摘要 | This invention relates to a peptide or a corresponding peptidomimetic that binds to an anti-KIR4.1 antibody in a sample from a patient, wherein said patient having multiple sclerosis or a predisposition therefor. The present invention furthermore relates to a method for diagnosing multiple sclerosis or a predisposition for multiple sclerosis in a subject, the method comprising determining the presence of an anti-KIR4.1 antibody in a sample obtained from said subject. Also provided are novel means and methods for the therapy of multiple sclerosis. | ||
| 申请公布号 | US9297809(B2) | 申请公布日期 | 2016.03.29 |
| 申请号 | US201214122318 | 申请日期 | 2012.05.23 |
| 申请人 | KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITÄT MÜNCHEN | 发明人 | Hemmer Bernhard;Srivastava Rajneesh |
| 分类号 | G01N33/53;G01N33/68;C07K16/28;C07K14/705 | 主分类号 | G01N33/53 |
| 代理机构 | DT Ward, PC | 代理人 | DT Ward, PC ;Ward Donna T.;Jia Lingyun |
| 主权项 | 1. A method for diagnosing multiple sclerosis or a predisposition for multiple sclerosis in a subject, the method comprising Contacting a sample obtained from said subject containing an anti-KIR4.1 antibody with a receptor specific for said anti-KIR4.1 antibody; and (b) detecting the formation of a receptor-anti-KIR4.1 antibody complex, wherein said receptor is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, KIR 4.1 protein SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and an antibody binding to said anti-KIR4.1 antibody, wherein the presence of an anti-KIR4.1 antibody in said sample is indicative of multiple sclerosis or a predisposition for multiple sclerosis. | ||
| 地址 | München DE | ||