Nanoparticulate assisted nanoscale molecular imaging by mass spectrometery

摘要

Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.

主权项

1. An analytical instrument for the characterization and analysis of a sample comprising:
a sample stage for positioning a sample; a nanoparticulate beam source positioned to deliver a nanoparticulate beam to a sample on said sample stage to deposit a matrix in the sample; wherein the nanoparticulate beam source comprises a nanoparticulate silver beam source or a nanoparticulate silver ion beam source; a nanofocused primary particle beam source, said nanofocused beam source positioned to deliver a beam to said sample including the matrix; and, an analyzer positioned to analyze material or photons emitted from said sample; wherein said nanofocused primary particle beam source comprises a nanofocused neon ion particle beam source.