Methods for inducing immune tolerance to organ transplants

摘要

The present invention is directed to methods of treating an organ or a tissue prior to transplantation thereof into a recipient, comprising ablating the cells composing the blood vessels of said organ or tissue, preferably the cells lining the lumen surface of the blood vessels, thereby obtaining a treated viable organ or tissue having reduced immunogenicity. The invention is also directed to treated viable organs or tissues having reduced immunogenicity and uses thereof.

主权项

1. A method of treating an organ or a tissue prior to transplantation thereof into a recipient, comprising:
(a) providing an organ or a tissue intended for transplantation; and (b) ablating the cells composing the blood vessels of said organ or tissue while keeping the remaining cell layers in the organ or the tissue intact and viable, thereby obtaining a treated viable organ or tissue having reduced immunogenicity.