Polymer nanoparticles coated by magnetic metal oxide and uses thereof

摘要

The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.

主权项

1. A nanoparticle comprising: a metal chelating polymer core, and a magnetic metal oxide coating, said magnetic metal oxide coating coats said metal chelating polymer core, and TNF-related apoptosis-inducing ligand (Apo-2L), covalently bound to said metal chelating polymer core, wherein covalently includes binding via an amino group of said metal chelating polymer and an amino group of said TNF-related apoptosis-inducing ligand.