Inhibition of bacterial biofilms and microbial growth with imidazole derivatives

摘要

Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.

主权项

1. A compound of Formula (I)(a)(i): wherein: R1a, R1b, and R2 are each H; R3a, R3b, R3c, R3d, and R3e are each independently selected from H and alkyl; and each occurrence of Rw, Rx, Ry, and Rz is present or absent (depending upon chain saturation), and is independently selected from the group consisting of: H and alkyl; n=3 to 6; and m=3 to 6; or a salt thereof; or a compound of Formula (I)(a)(ii): wherein: R1a, R1b, and R2 are each H; R4a, R4b, R4c, R4d, and R4e are each independently selected from H and alkyl; and each occurrence of Rw, Rx, Ry, and Rz is present or absent (depending upon chain saturation), and is independently selected from the group consisting of: H and alkyl; n=3 to 6; and m=3 to 6; or a salt thereof.