Transmission-reflectance swappable Raman probe for physiological detections

摘要

A transmission-reflectance swappable Raman device and a method thereof are disclosed. The excitation light is selectively directed to the sample in one direction for generating the transmission Raman signal in transmission mode or in another direction for generating the reflectance Raman signal in reflectance mode. The content of an analyte in a sample can be determined by analyzing transmission and reflectance Raman signal.

主权项

1. An optical signal detection device, comprising:
a frame; an excitation light source coupled to said frame and configured to generate an excitation light; a sample space disposed within said frame and adapted to receive a sample during operation; a detector coupled to said frame and configured to capture transmission optical signal and reflectance optical signal generated by said sample when said excitation light is directed to said sample during operation; and an optical component coupled to said frame and positioned between said sample space and said detector for reflecting said excitation light and transmitting said transmission optical signal and said reflectance optical signal; wherein said device is switchable between a transmission mode and a reflectance mode of operation; wherein in said transmission mode said excitation light source is positioned to direct said excitation light to said sample in a first direction for generating said transmission optical signal during operation; wherein in said reflectance mode said frame is configured to direct said excitation light to said optical component, said optical component reflecting said excitation light to said sample along a signal axis in a second direction opposite to said first direction for generating said reflectance optical signal; wherein said frame further includes a rotatable stage that generates relative displacement between said excitation light source and said optical component; thereby when said device switches from said transmission mode to said reflectance mode, said rotatable stage rotates from zero degree to no more than ninety degrees with respect to said signal axis so that said excitation light is directed to said optical component.