Method for identifying malignancies in barrett's esophagus using white light endoscopy

摘要

A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

主权项

1. A method for assessing cancer risk by diffuse reflectance spectroscopy, comprising:
directing light from a source to an area of esophageal tissue with an endoscope to provide wide field illumination of a surface of the tissue, the light having a wavelength range that includes at least a portion of the visible spectrum; measuring, with a reflectance probe, intensity of diffusely reflected light in at least four distinct narrow wavelength bands at different tissue sampling sites, said at least four bands being in the wavelength range of the illumination light, two of said bands being in the blue light range, and two of said bands being in the red light range; computing a parameter value for each of the different tissue sampling sites, the parameter being a predetermined linear discriminate function based on said intensity measurements; and assessing malignancy of the tissue based on the computed parameter values from the different tissue sampling sites.