Quilted implantable graft

摘要

Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

主权项

1. A multilayer surgical graft, comprising:
a first remodelable extracellular matrix sheet having an inward-facing surface and an outward-facing surface opposite said inward-facing surface, said outward-facing surface of said first remodelable extracellular matrix sheet forming a first outermost surface of said surgical graft; a second remodelable extracellular matrix sheet having an inward-facing surface; and a synthetic mesh material with a plurality of closed-circumference mesh openings disposed between said first remodelable extracellular matrix sheet and said second remodelable extracellular matrix sheet, said closed-circumference mesh openings defined by the synthetic mesh material so as to have closed circumferences; said inward-facing surface of said first remodelable extracellular matrix sheet and said inward-facing surface of said second remodelable extracellular matrix sheet contacting one another through said plurality of closed-circumference mesh openings including through a first closed-circumference mesh opening to provide a first contacting region between said inward-facing surface of said first remodelable extracellular matrix sheet and said inward-facing surface of said second remodelable extracellular matrix sheet, wherein said inward-facing surface of said first remodelable extracellular matrix sheet is bonded to said inward-facing surface of said second remodelable extracellular matrix sheet in said first contacting region to form a first bonded region, and wherein said first bonded region occurs within a surface depression on said first outermost surface of said surgical graft, wherein the surface depression on said first outermost surface occurs adjacent to raised portions of said first outermost surface, said raised portions positioned over members of said synthetic mesh material that define said closed-circumference mesh openings; and a first open passageway for allowing passage of fluids through the open passageway from a first side of the surgical graft to a second side of the surgical graft, the first open passageway extending through said first remodelable extracellular matrix sheet, through said first closed-circumference mesh opening, and through said second remodelable extracellular matrix sheet within said first bonded region; wherein said first bonded region extends laterally beyond and fully around said first open passageway.