Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof

摘要

The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.

主权项

1. A method for treating breast cancer comprising administering to a subject in need thereof a therapeutically effective amount of the mTOR inhibitor: or a pharmaceutically acceptable salt thereof; and a therapeutically effective amount of the PI3-kinase α inhibitor: or a pharmaceutically acceptable salt thereof.