发明名称 |
Combination therapy for proliferative disorders |
摘要 |
The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation. |
申请公布号 |
US9295669(B2) |
申请公布日期 |
2016.03.29 |
申请号 |
US201113313042 |
申请日期 |
2011.12.07 |
申请人 |
Hoffman La-Roche Inc. |
发明人 |
Dhingra Kapil;Higgins Brian;Kolinsky Kenneth;Lee Richard J.;Lestini Brian;Packman Kathryn;Su Fei |
分类号 |
A61K31/535;A61K31/505;A61K38/21;A01N43/54;A01N43/42;C07D413/00;C07D239/02;C07D401/00;C07D403/00;C07D471/02;A61K31/437 |
主分类号 |
A61K31/535 |
代理机构 |
Morrison & Foerster LLP |
代理人 |
Morrison & Foerster LLP |
主权项 |
1. A method of treating a patient suffering from a proliferative disorder, comprising administering to the patient: (A) a first component which comprises, as an active agent, propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]amide}, or a pharmaceutically acceptable salt thereof; and (B) a second component which comprises, as an active agent, peginterferon alfa-2a;
wherein said propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]amide} is administered in an amount of from about 1700 mg/day to about 2100 mg/day, wherein said amount is about 25 mg/kg, and said peginterferon alfa-2a is administered in an amount of from about 180 μg/week to about 630 μg/week, and wherein said proliferative disorder is selected from the group consisting of: colorectal cancer, melanoma, and thyroid cancer, wherein said cancer involves a tumor comprising b-Raf having the V600E mutation. |
地址 |
Nutley NJ US |